‍Estriol 0.3% | Niacinamide 3% | Hyaluronic acid 0.5%

‍45g airless pump. 60-day supply. Prescription only.

How to order

E3 Face Cream is a prescription product and is dispensed after clinical review.

1. Book your consultation
A video consultation with one of our doctors. Short or long, whichever suits what you want to discuss.

2. Your doctor decides
They review your history and check that E3 is appropriate for you. If it isn't, we won't dispense it, and you won't be charged for the product.

3. You approve your plan
Review the prescription, confirm your delivery address and add a card. This is the last step that needs anything from you.

4. E3 arrives every 60 days
One 45g pump, sent automatically. No reordering, no repeat consultation between reviews.

5. Annual review
Your prescription is valid for twelve months. We'll remind you before it expires so you can book your review and keep deliveries running.

Pause, skip or cancel at any time from your account. We'll email you before every charge, so nothing arrives as a surprise.

Delivery

Each order is dispensed and delivered within 3 working days. Delivery is within Singapore only.

You will receive a notification when your order is on its way. If nothing has arrived after 3 working days, contact us and we will trace it.

Storage and shelf life

E3 Face Cream is a prescription product and contains no synthetic preservatives beyond what is needed for stability. We recommend using it within 6 months of receiving it.

Store it at room temperature, away from direct sunlight and heat.

Do not use E3 after the recommended period, and do not share it with anyone else. It has been prescribed for you.

What is E3 Face Cream about?

E3 Face Cream is a prescription night cream for skin that has changed with perimenopause and menopause. It pairs low-dose estriol, a milder form of oestrogen, with two barrier-supporting actives in a base formulated for facial skin.

Most skincare treats menopausal skin as ordinary dry skin. It isn't. The changes are driven by falling oestrogen, and E3 is designed to work at that level.

Why skin changes during perimenopause and menopause

Skin is an oestrogen-responsive organ. Oestrogen receptors sit in the epidermis, the dermis, hair follicles and sweat glands, and oestrogen helps regulate collagen production, skin thickness, water-holding capacity and wound healing.¹

As oestrogen falls, women commonly notice:

• Persistent dryness, tightness and flaking that moisturiser no longer fixes
• Thinner, more fragile, more easily irritated skin
• Loss of firmness and elasticity, with lines appearing more quickly
• Dullness and uneven tone
• Slower healing and more visible bruising

Collagen loss is fastest in the first five years after menopause, which is why skin can seem to change abruptly rather than gradually.¹

How topical estriol works

If you want to target facial skin directly, topical estriol is an option that has been studied specifically for menopausal skin changes.

Estriol is a weaker oestrogen than estradiol. Applied to the skin, it acts on local oestrogen receptors and may help support collagen, skin thickness and elasticity where it is applied.

One study compared estriol and estradiol creams used on the face over six months in perimenopausal women. Both improved signs of skin ageing, with slightly greater improvement seen with estriol.² Skin biopsies examined under the microscope have also shown increased skin thickness and improved elastic fibre structure with topical estriol.²

Importantly, blood tests in that study showed no significant change in hormone levels, which suggests the treatment worked mainly where it was applied.²

What the evidence says about systemic absorption

This is the question most women ask first, and the honest answer is that the data is limited but reassuring.

Several studies of cosmetic creams containing estriol or estradiol have monitored hormone-related markers to test for systemic absorption. Most found no evidence of it. FSH, serum estradiol and vaginal cytology generally remained unchanged.²

One study reported breast tenderness in some participants. As there was no placebo group, it was not possible to tell whether the cream caused it, and the authors concluded that no systemic hormonal side effects were observed.²

The overall picture is that systemic oestrogenic effects from topical facial estriol at cosmetic doses are likely to be minimal. We will say plainly that the evidence base is small, and we will keep reviewing it.

Why estriol is combined with niacinamide and hyaluronic acid

Low-dose estriol on its own is not a complete formulation for facial skin. E3 combines it with actives chosen to support the barrier and reduce the chance of irritation:

Niacinamide (vitamin B3) 3%
Supports the skin barrier, improves tone and texture, and helps calm redness.

Hyaluronic acid 0.5%
Helps skin hold water and eases the dryness that comes with falling oestrogen.

Facial-grade base
Formulated specifically for delicate facial skin, and free of ingredients likely to cause unnecessary irritation. Delivered in an airless pump to keep the actives stable.

How to use

E3 is a night product. Use it once daily in the evening.

1. Cleanse your face
2. Apply any toner or serum you normally use
3. Apply 1 to 2 pumps of E3 Face Cream to face and neck
4. Follow with your night moisturiser, and any retinol if you use one

Apply a thin layer. More is not better. Use as directed by your doctor.

Skin turnover is slow, so give it three to six months before judging results. The published facial studies ran for six months.²

Suitability and safety

E3 Face Cream is suitable for all skin types, including sensitive skin, and is safe to use alongside your other skincare.

It is also safe to use with Menopausal Hormone Therapy. A clinical study found no increase in blood estriol levels after use.²

Before you start

• Patch test for a few days. Apply a small amount to one area of your face or neck and watch for a reaction.
• Discontinue if irritation occurs.
• If you have a history of melasma, start with a very small amount and increase slowly. Discontinue if your melasma worsens.
• Tell your doctor about any history of oestrogen-sensitive cancer, unexplained vaginal bleeding, or current pregnancy or breastfeeding, before starting.

References

1. Verdier-Sévrain S, Bonté F, Gilchrest B. Biology of estrogens in skin: implications for skin aging. Experimental Dermatology. 2006.
2. Schmidt JB, Binder M, Macheiner W, Kainz C, Gitsch G, Bieglmayer C. Treatment of skin ageing symptoms in perimenopausal females with estrogen compounds. A pilot study. Maturitas. 1994;20(1):25-30.
3. Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. International Journal of Dermatology. 1996;35(9):669-74.
4. Troxel J, Ferrer L, Iwamoto A, et al. Topical estrogen therapy for aging skin: current evidence and clinical considerations.

Terms and Conditions

E3 Face Cream is supplied only after clinical review and a valid prescription. Placing an order does not guarantee supply. If our doctor assesses that E3 is not clinically appropriate for you, we will not dispense it, and you will not be charged for the product.

Consultations purchased online must be scheduled and completed within three (3) months from the date of purchase. Failure to schedule or complete the consultation within this timeframe may result in forfeiture of the consultation without eligibility for a refund.

Billing and repeat delivery
By approving your treatment plan, you authorise Taylor to charge your nominated card for each E3 Face Cream delivery, every 60 days, until your prescription expires or you cancel. We will email you before each charge. You may pause, skip or cancel at any time from your account, provided you do so at least 2 working days before your next scheduled charge. Cancelling stops future deliveries. It does not refund a delivery that has already been dispensed.

Prescription validity
Prescriptions are valid for twelve (12) months from the date of issue. Deliveries will stop automatically when your prescription expires. To resume, book your annual video consultation. We will remind you in advance.

Taylor reserves the right to update the information or fees associated with this product without prior notice.

By placing an order, you consent to Taylor's Terms and Conditions and Privacy Policy.

Returns and Cancellation Policy

For safety and regulatory reasons, dispensed prescription medicines cannot be returned, exchanged or refunded once they have left our pharmacy. This includes change of mind, and it includes products that have not been opened. We seek your understanding for this.

We will refund or replace an order in the following scenarios:

• The product arrives damaged, leaking or with a faulty pump
• You receive the wrong product or the wrong strength
• A system error results in a duplicated order or an order error
• Taylor is unable to supply the product ordered

Report any damaged or incorrect item within 3 days of delivery, with a photograph, and we will replace it at no cost.

Orders can be cancelled without charge at any point before dispensing. Once an order has been dispensed, it cannot be cancelled.

If you develop a reaction to E3, stop using it and contact us. If warranted, we will arrange a follow-up review with your doctor at no charge.